Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/259104290?client_source=feed&format=rss
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Tuesday, October 30, 2012
Sunday, October 28, 2012
Eddie Abbew in Back training Part 2 and Big boys Dean Ash ...
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Source: http://stek.org/videos/eddie-abbew-in-back-training-part-2-and-big-boys-dean-ash/
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Saturday, October 27, 2012
New opportunity for rapid treatment of malaria
Friday, October 26, 2012
Researchers have identified a new means to eradicate malaria infections by rapidly killing the blood-borne Plasmodium parasites that cause the disease.
Malaria causes up to 3 million deaths each year, predominantly afflicting vulnerable people such as children under five and pregnant women, in tropical regions of Africa, Asia, and Latin America. Treatments are available for this disease, but the Plasmodium parasite is fast becoming resistant to the most common drugs, and health authorities say they desperately need new strategies to tackle the disease.
This new potential treatment uses molecules that interfere with an important stage of the parasite's growth cycle and harnesses this effect to kill them. The impact is so acute it kills ninety per cent of the parasites in just three hours and all those tested in laboratory samples of infected human blood cells, within twelve hours.
The research was carried out by chemists at Imperial College London and biological scientists from the research institutions Institut Pasteur and CNRS in France. Their work is published in the journal Proceedings of the National Academy of Sciences (PNAS).
Lead researcher Dr Matthew Fuchter, from Imperial College London, said: "Plasmodium falciparum causes 90 per cent of malaria deaths, and its ability to resist current therapies is spreading dramatically. Whilst many new drugs are in development, a significant proportion are minor alterations, working in the same way as current ones and therefore may only be effective in the short term. We believe we may have identified the parasite's 'Achilles' Heel', using a molecule that disrupts many vital processes for its survival and development."
The research has identified two chemical compounds that affect Plasmodium falciparum's ability to carry out transcription, the key process that translates genetic code into proteins. These compounds are able to kill the parasite during the long period of its complex life cycle while it inhabits the blood-stream. This is in contrast to the majority of antimalarial drugs, whose action is limited to shorter stages of Plasmodium's life cycle.
"One particularly exciting aspect of this discovery is this new molecule's ability to rapidly kill off all traces of the parasite, acting at least as fast as the best currently available antimalarial drug," said Dr Fuchter.
Initial tests also showed the molecules were able to kill strains of Plasmodium that have developed a resistance to current treatments, although the scientists say more experiments are needed to confirm these results.
The scientists hope to refine these molecules, improving their effectiveness and proving this to be a viable strategy for treating malaria in humans. They hope it will lead to the development of an effective malaria cure within the next ten years.
###
"Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum" is published in Proceedings of the National Academy of Sciences (PNAS) by Nicholas A. Malmquist, Thomas A. Moss, Salah Mecheri, Artur Scherf, Matthew J. Fuchter. doi: 10.1073/pnas.1205414109 http://www.pnas.org/content/109/41/16708.abstract
Imperial College London: http://www.imperial.ac.uk/press
Thanks to Imperial College London for this article.
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Source: http://www.labspaces.net/124826/New_opportunity_for_rapid_treatment_of_malaria
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10 Filthy-Rich, Tax-Dodging Hypocrites Pushing Disastrous ...
Brace yourself for one of the most aggressive corporate lobbying campaigns of all time. And one of the most hypocritical.
The irony is that CEOs in the coalition?s leadership have been major contributors to the national debt they now claim to know how to fix. These are guys who?ve mastered every tax-dodging trick in the book. And now that they?ve boosted their corporate profits by draining the public treasury, how do they propose we put our fiscal house back in order? By squeezing programs for the poor and elderly, including Social Security, Medicare, and Medicaid.
Fix the Debt claims their agenda is not just about spending cuts. But when it comes to their tax proposals, they use the slippery term ?pro-growth reform? to push for cuts in deductions that are likely to include credits for working families and ? you guessed it ? more corporate tax breaks. Chief among these is a proposal to switch to a territorial system under which corporate foreign earnings would be permanently exempted (instead of being taxed when they are returned to America).
This idea, also supported by the Bowles-Simpson deficit commission, would make it even more profitable for big corporations to use accounting tricks to disguise U.S. profits as income earned in tax havens. Citizens for Tax Justice estimates that such tax haven abuse will cost the Treasury more than $1 trillion over the next decade.
So who are the CEOs who are telling the rest of us to be responsible and tighten our belts after they?ve spent decades stiffing the U.S. Treasury? Of the 80 members of Fix the Debt?s CEO Fiscal Leadership Council, here are 10 that stand out as the biggest hypocrites:
1. Jeffrey Immelt, General Electric
Perhaps no tax-dodging U.S. corporation has done more to drain the U.S. Treasury than General Electric. Over the last 10 years GE reported more than $80 billion in U.S. pre-tax profits and yet paid a federal corporate income tax rate of just 2.3% .
One of GE?s favorite tricks is the ?Active Financing Exception.? U.S. corporations are supposed to pay U.S. taxes on interest income earned anywhere in the world. But GE enjoys this special exception for companies that have ?captive? foreign finance subsidiaries, such as their credit card arm. The measure was repealed as part of fair taxation reforms in 1986, but GE led a successful lobbying effort to bring it back in 1997. Although the exception was supposed to be temporary, Congress has renewed it six times. And, despite all the public hand-wringing over the deficit, lawmakers are seriously considering extending this and other corporate loopholes before the end of the year.
2. Jim McNerney, Boeing
Last year, Boeing was one of 25 major U.S. firms that paid their CEO more than they paid Uncle Sam in corporate income taxes, according to an Institute for Policy Studies report . The aerospace giant enjoyed a $605 million tax refund in 2011, despite reporting more than $5 billion in U.S. pre-tax profits. CEO Jim McNerney made $18.4 million in personal compensation. In fact, Boeing is a serial tax dodger , having paid federal corporate income taxes in only two of the last 10 years.
One of the ways Boeing avoids paying taxes is by taking advantage of the Research and Experimentation Tax Credit, which saved the $137 million last year alone. Government investment in basic research is not a bad idea, but current R&D credits are structured in a way that primarily benefits large, well-resourced high-tech firms like Boeing that would probably do the research anyway. CEO McNerney also chairs the Business Roundtable, which aggressively lobbies for more corporate tax breaks.
3. Lloyd Blankfein, Goldman Sachs
Few corporations have been as dependent on U.S. taxpayers for their very existence as Goldman Sachs. The 2008 bailout of American International Group and the steady stream of low- and non-interest loans for the financial sector have kept the company alive.
CEO Blankfein says he?d accept a small increase in individual taxes for the wealthy in exchange for a comprehensive budget deal. But his corporate tax proposals would wipe out the revenue gains from rolling back the Bush tax cuts for top earners. Blankfein is a big supporter of the territorial tax system explained above. This is hardly a surprise, since Goldman Sachs already operates 37 subsidiaries in tax havens .
Blankfein has also used his position at the helm of the Financial Services Forum, a club for the CEOs of 20 top banks, to oppose financial transaction taxes -- small levies on trades of stock, derivatives, and other financial instruments. Goldman Sachs has made as much as $300 million per year from the volatile high-frequency trading strategies that would be hardest hit by such a transaction tax. In early October, 11 European governments announced a plan to implement such taxes, with expected revenues in the neighborhood of $ 75 billion per year . But Goldman Sachs and other Wall Street firms have blocked U.S. progress on this major revenue-raiser.
4. Brian T. Moynihan, Bank of America
After a decade of risky?and reckless mortgage lending, Bank of America survived the 2008 financial crash with the help of a $45 billion bailout. Today, Bank of America sits on $128 billion in cash ? $18 billion of it is overseas ?and much of that is sitting in the company?s 115 tax haven subsidiaries .
Last year, after investors saw their stock price decline 58 percent and 30,000 Bank of America employees lost their jobs to layoffs, CEO Brian Moynihan saw his compensation quadruple to more than $8 million. His predecessor, Ken Lewis, raked in more than $50 million in the two years?before the housing bubble that Bank of America had help inflate burst in 2008.
5. David Cote, Honeywell Corporation
Over the last three years, Honeywell received more than $2.7 billion in federal defense contracts and reported more than $2.5 billion in U.S. pre-tax profits. And yet thanks to corporate deductions, tax subsidies, and loopholes, Honeywell has claimed $377 million in federal tax refunds during this period.
Honeywell CEO David Cote has been a fixture at Congressional hearings calling for a territorial tax system for corporations. He is also Vice-Chair of the Business Roundtable, a club for big business CEOs that has called for an extension of all the Bush tax cuts, including those for millionaires and billionaires, as well as the tax cuts on unearned income from capital gains and dividends. These combined measures would add $1.5 trillion to the debt over the next ten years.
6. Randall Stephenson, AT&T
AT&T is another firm that paid its CEO more last year than they paid in federal corporate income taxes. CEO Randall Stephenson made $18.7 million , while the firm enjoyed a $420 million refund from Uncle Sam.
AT&T is a major beneficiary of ?accelerated depreciation? rules that allow companies to turbo-charge tax deductions in the early years of the life of an asset. A 2009 accelerated depreciation rule saved the company $5.2 billion on their 2011 taxes, according to the firm?s 10-K report. Although touted as a way to jumpstart spending in a downturn, such tax breaks often result in taxpayers bearing a substantial portion of the cost of investments firms would?ve made anyway.
7. Arne Sorenson, Marriott International
In 2009, the U.S. Department of Justice prosecuted Marriott International for using an illegal tax shelter swindle dubbed ? Son of Boss .? The scam involved setting up a series of complex paper transactions between company subsidiaries to create $70 million in fake losses that could be offset against Marriott?s real profits. Presidential candidate Mitt Romney, a long-time friend of the Marriott family and named after Marriott?s patriarch J. Willard Marriott, was the head of the hotel giant?s audit committee in 1994 at the time the board first approved the Son of Boss transaction. According to Bloomberg, Marriott has also shifted profits to a Luxembourg shell company and avoided hundreds of millions of dollars in taxes through one federal tax credit for so-called synthetic fuel that Senator John McCain dubbed an ?expensive hoax.?
8. Alexander Cutler, Eaton Corporation
Less than two years after accepting $90 million in taxpayer-financed subsidies to locate a new world headquarters in the suburbs of Cleveland, Eaton Corporation announced that it would be moving its headquarters and reincorporating as an Irish company. The move is part of a merger deal with Cooper Industries, another Fix the Debt coalition member. The two companies boast that Eaton?s departure after 100 years in Cleveland will cut their tax bill by $160 million . Meanwhile, Eaton is fighting a $75 million bill from the IRS for back taxes and penalties related to alleged violations of transfer pricing agreements.
9. Lowell McAdam, Verizon
Verizon is one of 30 companies identified by Citizens for Tax Justice as having paid ?less than nothing? in federal income taxes over the entire 2008-10 period. Despite earning $32.5 billion in profits during these three years, the firm got so much in tax subsidies that they wound up with a net tax refund of $951 million. That works out to a tax rate of negative 2.9%. In effect, every Verizon phone customer paid more in federal telephone excise taxes than Verizon paid in federal income taxes.
10. Steve Ballmer, Microsoft
A recent Senate investigation exposed how Microsoft has used Olympic class accounting acrobatics to avoid paying taxes. Specifically, the Senate Permanent Subcommittee on Investigations charged that the software giant had devised a complicated transfer pricing agreement with a subsidiary in Puerto Rico to lower its tax bill on goods sold in the U.S. market by as much as $4.5 billion from 2009 to 2011. The investigation also accused Microsoft of avoiding billions in U.S. corporate income taxes by shifting royalty revenue to low-tax jurisdictions. Subcommittee Chair Carl Levin described Microsoft?s strategies as ?tax alchemy, featuring structures and transactions that require a suspension of disbelief to be accepted.? Such alchemy, while not illegal, is a major contributor to the?national debt.
Sanders to CEOs: Look in the Mirror
When Fix the Debt launched their 80 CEO-strong coalition on October 25, Senator Bernie Sanders responded by stating, ?Before telling us why we should cut Social Security, Medicare and other vitally important programs, these CEOs might want to take a hard look at their responsibility for causing the deficit and this terrible recession.?
Instead, the Fix the Debt coalition members are portraying themselves as the honorable ones who are brave enough to push the tough austerity medicine that is the only remedy for our fiscal ills. Nonsense. We are the richest nation in the history of the world. Our problem is that too much of our wealth is going into the coffers of rich individuals and corporations and to pay for misguided wars.
There are numerous budget plans by Senator Sanders, the Congressional Progressive Caucus, and others that would get us on the right track. At the Institute for Policy Studies , we?ve identified a dozen policies that would collectively raise trillions of dollars to in ways that would not only address the fiscal challenge but help make our economy more equitable, green, and secure. The report also points out that until we recover from the current unemployment crisis, we should not be contemplating any spending cuts that could deepen the crisis.
The Fix the Debt coalition is using the so-called ?fiscal cliff? as an opportunity to push the same old corporate agenda of more tax breaks while shifting the burden on to the middle class and the poor. If America?s CEOs really want to Fix the Debt, they should first commit to eliminating the loopholes that have allowed them to avoid paying their fair share of the cost of government, including investments necessary to keep our families and our communities strong and secure.
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Friday, October 26, 2012
Shot Pakistani girl "will rise again": father
BIRMINGHAM, England (Reuters) - The father of a Pakistani girl who was shot in the head by the Taliban for advocating girls' education said on Friday his daughter was strong and would "rise again" to pursue her dreams after receiving treatment in a British hospital.
Malala Yousufzai, 15, was flown from Pakistan to the British city of Birmingham to receive specialist treatment after the October 9 attack which drew widespread international condemnation.
She has become a powerful symbol of resistance to the radical Islamist group's effort to deny women an education.
Her father, Ziauddin Yousufzai, and other family members flew to Britain on Thursday to help their daughter's recovery.
"They wanted to kill her. But she fell temporarily. She will rise again. She will stand again," he said, his voice wavering and breaking with emotion as he spoke.
"It's a miracle for us ... She was in a very bad condition," he told reporters, sitting alongside his son.
"She is improving with encouraging speed."
Yousufzai began standing up to the Pakistani Taliban when she was 11, when the Islamabad government had effectively ceded control of the Swat Valley where she lives to the militants.
She has been in critical condition since gunmen shot her in the head and neck as she left school in Swat, northwest of Islamabad.
British doctors say she has every chance of making a good recovery at the special hospital unit, expert in dealing with complex trauma cases. It has treated hundreds of soldiers wounded in Afghanistan.
Her father said he and his family cried when they were finally reunited with Malala on Thursday. "We are very happy," he said. "I pray for her."
(Reporting by Stephen Eisenhammer, Writing by Maria Golovnina; editing by Steve Addison)
Source: http://news.yahoo.com/shot-pakistani-girl-recovering-fast-uk-father-103912733.html
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East Coast braces for monster 'Frankenstorm'
Map shows path of Hurricane Sandy
Map shows path of Hurricane Sandy
This NOAA satellite image taken Thursday, October 25, 2012 at 10:45 AM EDT shows Hurricane Sandy over the Bahamas with maximum sustained winds of 105 mph and moving toward the north. Farther north, a cold front moves into the Great Lakes and Ohio Valley with showers and thunderstorms. (AP PHOTO/WEATHER UNDERGROUND)
A woman cries out in front of her flooded house caused by heavy rains from Hurricane Sandy in Port-au-Prince, Haiti, Thursday, Oct. 25, 2012. Hurricane Sandy rumbled across mountainous eastern Cuba and headed toward the Bahamas on Thursday as a Category 2 storm, bringing heavy rains and blistering winds. (AP Photo/Dieu Nalio Chery)
A fallen tree and toppled light poles block a road in Kingston, Jamaica, after the passing of Hurricane Sandy, Thursday, Oct. 25, 2012. Sandy, which made landfall Wednesday afternoon near Kingston, crossed over Jamaica killing an elderly man when a boulder crashed into his clapboard house, police said. (AP Photo/Collin Reid)
Residents wade through a flooded street caused by heavy rains from Hurricane Sandy in Port-au-Prince, Haiti, Thursday, Oct. 25, 2012. Hurricane Sandy rumbled across mountainous eastern Cuba and headed toward the Bahamas on Thursday as a Category 2 storm, bringing heavy rains and blistering winds. (AP Photo/Dieu Nalio Chery)
WASHINGTON (AP) ? The pre-Halloween hybrid weather monster that federal forecasters call "Frankenstorm" is looking more ominous by the hour for the East Coast, and utilities and local governments are getting ready.
Meteorologists expect a natural horror show of high wind, heavy rain, extreme tides and maybe snow to the west beginning early Sunday, peaking with the arrival of Hurricane Sandy on Tuesday and lingering past Halloween on Wednesday.
With a rare mix of three big merging weather systems over a densely populated region, experts predict at least $1 billion in damage.
The stage is set as Hurricane Sandy, having blown through Haiti and Cuba, continues to barrel north. A wintry storm is chugging across the country from the west. And frigid air is streaming south from Canada.
And if they meet Tuesday morning around New York or New Jersey, as forecasters predict, they could create a big, wet mess that settles over the nation's most heavily populated corridor and reaches as far west as Ohio.
Utilities are lining up out-of-state work crews and canceling employees' days off to deal with expected power outages. From county disaster chiefs to the federal government, emergency officials are warning the public to be prepared. And President Barack Obama was briefed aboard Air Force One.
"It's looking like a very serious storm that could be historic," said Jeff Masters, meteorology director of the forecasting service Weather Underground. "Mother Nature is not saying, 'Trick or treat.' It's just going to give tricks."
National Oceanic and Atmospheric Administration forecaster Jim Cisco, who coined the nickname Frankenstorm, said: "We don't have many modern precedents for what the models are suggesting."
Government forecasters said there is a 90 percent chance ? up from 60 percent two days earlier ? that the East will get pounded.
Coastal areas from Florida to Maine will feel some effects, but the storm is expected to vent the worst of its fury on New Jersey and the New York City area, which could see around 5 inches of rain and gale-force winds close to 40 mph. Eastern Ohio, southwestern Pennsylvania and western Virginia could get snow.
And the storm will take its time leaving. The weather may not start clearing in the mid-Atlantic until the day after Halloween and Nov. 2 in the upper Northeast, Cisco said.
"It's almost a weeklong, five-day, six-day event," he said from a NOAA forecast center in College Park, Md. "It's going to be a widespread, serious storm."
It is likely to hit during a full moon, when tides are near their highest, increasing the risk of coastal flooding. And because many trees still have their leaves, they are more likely to topple in the event of wind and snow, meaning there could be widespread power outages lasting to Election Day.
Eastern states that saw outages that lasted for days after last year's freak Halloween snowstorm and Hurricane Irene in late August 2011 are already pressuring power companies to be more ready this time.
Asked if he expected utilities to be more prepared, Massachusetts Gov. Deval Patrick responded: "They'd better be."
Jersey Central Power & Light, which was criticized for its response to Irene, notified employees to be ready for extended shifts. In Pennsylvania, PPL Corp. spokesman Michael Wood said, "We're in a much better place this year."
New York Mayor Michael Bloomberg on Thursday said the city was striking a tone of calm preparedness.
"What we are doing is we are taking the kind of precautions you should expect us to do, and I don't think anyone should panic," Bloomberg said. The city has opened an emergency situation room and activated its coastal storm plan.
Some have compared the tempest to the so-called Perfect Storm that struck off the coast of New England in 1991, but that one hit a less populated area. Nor is this one like last year's Halloween storm, which was merely an early snowfall.
"The Perfect Storm only did $200 million of damage and I'm thinking a billion" this time, Masters said. "Yeah, it will be worse."
As it made its way across the Caribbean, Sandy was blamed for more than 20 deaths. The 18th named storm of the Atlantic hurricane season hit the Bahamas after cutting across Cuba, where it tore roofs off homes and damaged fragile coffee and tomato crops.
Norje Pupo, a 66-year-old retiree in Holguin, was helping his son clean up early Thursday after an enormous tree toppled in his garden.
"The hurricane really hit us hard," he said. "As you can see, we were very affected. The houses are not poorly made here, but some may have been damaged."
___
Associated Press writers Tony Winton in Miami, Fernando Gonzalez in Cuba, Ken Thomas on Air Force One, Michael Rubinkam in Harrisburg, Pa., and Karen Matthews in New York contributed to this report.
___
Seth Borenstein can be followed at http://twitter.com/borenbears
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